Awesome AI AgentsMulti-Agent Frameworks

aristoteleo/pantheon-cli

⭐ 485 Python repository created 2025-07-30

PantheonOS, distributed as the pantheon-agents package with a pantheon command line entry point, is a multi-agent framework from a Stanford-affiliated group that targets data science work and in particular end-to-end single-cell and spatial transcriptomics analysis. Agents are composed into teams using several orchestration patterns: a general PantheonTeam, sequential pipelines, swarms, mixture-of-agents and a pattern that exposes one agent as a tool to another. Communication between agents runs over NATS messaging, which lets a deployment span several machines and tolerate node failure; a companion component called Pantheon-Fleet uses the same transport to let agents drive a network of machines directly. The Pantheon-Evolve module applies genetic-algorithm-driven code evolution so that agents iteratively rewrite and benchmark algorithm implementations, which the authors present as a way to improve on published methods for specialized scientific tasks. Users interact through an interactive REPL started with pantheon cli, a multi-agent chatroom web interface, a hosted web application or a desktop build; an accompanying store distributes community-contributed agents, teams and skills for biomedical work. Installation is available through pip or uv with optional extras for retrieval-augmented knowledge, R language support and a mobile gateway, and a Docker image runs the stack in standalone mode. The project records replayable trajectories of agent runs. Its README documents a supply-chain incident in mid-2026 in which two trojanized package releases were published and later removed, with advice to reinstall and rotate credentials for anyone who installed those versions. The framework suits computational biologists and data scientists who want agentic automation of analysis pipelines, and more generally developers who need a distributed multi-agent runtime with built-in team topologies and code-evolution search.

https://github.com/aristoteleo/pantheon-cli

multi-agentagent-frameworkdistributed-systemsclisingle-cellspatial-transcriptomicsbioinformaticspython

Also in Multi-Agent Frameworks

affaan-m/ECC

ECC is a harness-native operator system designed for agentic AI work, providing a comprehensive solution with skills, memory optimization, security, and research-first development across multiple A...

ruvnet/ruflo

Ruflo is a leading agent orchestration platform for Claude, enabling the deployment of intelligent multi-agent swarms, coordination of autonomous workflows, and building conversational AI systems.

Yeachan-Heo/oh-my-claude-sisyphus

Oh My Claude Sisyphus (OMC) is a multi-agent orchestration framework for Claude Code, simplifying complex AI agent workflows without a steep learning curve.

microsoft/JARVIS

JARVIS is a collaborative AI system that connects large language models with expert AI models from HuggingFace to autonomously plan, execute, and integrate complex AI tasks.

rowboatlabs/rowboat

Rowboat is an AI-powered platform that enables users to build and manage multi-agent swarms using natural language, integrating tools and knowledge for automated workflows and deployment via API or SDK.

cft0808/edict

Edict is an OpenClaw Multi-Agent Orchestration System featuring 9 specialized AI agents, a real-time dashboard, model configuration, and full audit trails, inspired by ancient Chinese imperial gove...

MemoriLabs/Memori

Memori is a versatile SQL native memory layer designed to enhance LLMs, AI agents, and multi-agent systems with advanced memory management, seamless integration, and high performance.

HKUDS/DeepCode

DeepCode is an open-source project that uses multi-agent AI systems to convert research papers and natural language into production-ready code through both CLI and web interfaces.